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Rosuvastatin Reduces Blood Viscosity in Patients with Acute Coronary Syndrome
Korean Circulation Journal ; : 147-153, 2016.
Article in English | WPRIM | ID: wpr-221733
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Wall shear stress contributes to atherosclerosis progression and plaque rupture. There are limited studies for statin as a major contributing factor on whole blood viscosity (WBV) in patients with acute coronary syndrome (ACS). This study investigates the effect of statin on WBV in ACS patients. SUBJECTS AND

METHODS:

We prospectively enrolled 189 consecutive patients (mean age, 61.3±10.9 years; 132 males; ST-segment elevation myocardial infarction, n=52; non-ST-segment elevation myocardial infarction, n=84; unstable angina n=53). Patients were divided into two groups (group I previous use of statins for at least 3 months, n=51; group II statin-naïve patients, n=138). Blood viscosities at shear rates of 1 s-1 (diastolic blood viscosity; DBV) and 300 s-1 (systolic blood viscosity; SBV) were measured at baseline and one month after statin treatment. Rosuvastatin was administered to patients after enrollment (mean daily dose, 16.2±4.9 mg).

RESULTS:

Baseline WBV was significantly higher in group II ([SBV group I vs group II, 40.8±5.9 mP vs. 44.2±7.4 mP, p=0.003], [DBV 262.2±67.8 mP vs. 296.9±76.0 mP, p=0.002]). WBV in group II was significantly lower one month after statin treatment ([SBV 42.0±4.7 mP, p=0.012, DBV 281.4±52.6 mP, p=0.044]). However, low-density lipoprotein cholesterol level was not associated with WBV in both baseline (SBV R2=0.074, p=0.326; DBV R2=0.073, p=0.337) and after one month follow up (SBV R2=0.104, p=0.265; DBV R2=0.112, p=0.232).

CONCLUSION:

Previous statin medication is an important determinant in lowering WBV in patients with ACS. However, one month of rosuvastatin decreased WBV in statin-naïve ACS patients.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Rheology / Rupture / Blood Viscosity / Cholesterol / Prospective Studies / Follow-Up Studies / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Atherosclerosis / Acute Coronary Syndrome / Rosuvastatin Calcium Type of study: Observational study / Prognostic study Limits: Humans / Male Language: English Journal: Korean Circulation Journal Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rheology / Rupture / Blood Viscosity / Cholesterol / Prospective Studies / Follow-Up Studies / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Atherosclerosis / Acute Coronary Syndrome / Rosuvastatin Calcium Type of study: Observational study / Prognostic study Limits: Humans / Male Language: English Journal: Korean Circulation Journal Year: 2016 Type: Article