Analysis of NF-κB and Clinical Prognostic Factors in Clear Cell Renal Cell Carcinoma
Korean Journal of Urological Oncology
; : 63-68, 2016.
Article
in Ko
| WPRIM
| ID: wpr-23460
Responsible library:
WPRO
ABSTRACT
PURPOSE:
A multi-subunit transcription factor NF-κB is associated with anti-apoptotic signals in several cancers including renal cell carcinoma (RCC). In this study, we investigated whether the expression levels of the NF-κB were related to the clinical properties of human renal cell carcinoma such as nuclear grade, TNM stage, and recurrence free survival. MATERIALS ANDMETHODS:
Patients who were diagnosed with clear cell RCC between January 2006 and February 2013 were included. Clinicopathological data and survival were investigated. The expressions of NF-κB were investigated by performing immunohistochemical staining on 61 clear cell RCC. The expression levels of NF-κB were divided two groups by the expression levels.RESULTS:
Results on the expression of NF-κB were not significant. Analysis of NF-κB expressions is not associated with any of the clinical properties including age, nuclear grade and TNM stage (p=0.613, p=0.059, p=0.107, p=0.570, and p=0.760, respectively). Also, a statistically correlation was not observed between recurrence free survival and NF-κB expression levels (p=0.573).CONCLUSIONS:
The expressions of the NF-κB were not associated with the clinical properties of clear cell RCC such as age, nuclear grade, TNM stage, and recurrence free survival.Key words
Full text:
1
Index:
WPRIM
Main subject:
Prognosis
/
Recurrence
/
Transcription Factors
/
Immunohistochemistry
/
Carcinoma, Renal Cell
Type of study:
Prognostic_studies
Limits:
Humans
Language:
Ko
Journal:
Korean Journal of Urological Oncology
Year:
2016
Type:
Article