Expression of fascin in human esophageal squamous cell carcinoma and its clinical significance / 南方医科大学学报
Journal of Southern Medical University
; (12): 1216-1219, 2011.
Article
in Zh
| WPRIM
| ID: wpr-235159
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of fascin, an actin bundling protein, in the development and progression of human esophageal squamous cell carcinoma (ESCC), and explore its association with the clinicopathologic characteristics and 5-year survival of the patients.</p><p><b>METHODS</b>Using tissue array and immunohistochemistry, the expression of fascin was determined in 241 ESCC tissues and the corresponding normal esophageal mucosal tissues.</p><p><b>RESULTS</b>ESCC tissues showed a significantly higher overexpression rate of fascin than the corresponding normal esophageal mucosal tissues (68.9% vs 15.5%, P<0.05). The overexpression of fascin was correlated to lymph node metastasis and TMN stage, but not to the patients' age, gender, tumor differentiation and general classification. Survival analysis showed that abnormal expression of fascin was associated with the 5-year survival rate of patients with ESCC.</p><p><b>CONCLUSIONS</b>The abnormal expression of fascin may play an important role in the progression of ESCC, and detection of fascin expression may have important prognostic values.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Prognosis
/
Esophageal Neoplasms
/
Carcinoma, Squamous Cell
/
Carrier Proteins
/
Lymphatic Metastasis
/
Metabolism
/
Microfilament Proteins
Type of study:
Prognostic_studies
Limits:
Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2011
Type:
Article