Flow cytometric quantitative analysis of multiple tumor suppressor gene 1 (MTS1) and cyclooxygenase-2 (COX-2) gene expressions in invasive breast cancers and their clinical significance / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 515-517, 2006.
Article
in Zh
| WPRIM
| ID: wpr-236945
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>The purpose of the present study was to explore the expression and clinical significance of multiple tumor suppressor gene 1 (MTS1) and cyclooxygenase-2 (COX-2) gene in invasive breast cancers.</p><p><b>METHODS</b>Flow cytometry was used to analyze the expression level of MTS1 and COX-2 in cancer tissues and corresponding para-cancer tissues from 66 cases of primary invasive breast cancers.</p><p><b>RESULTS</b>In breast cancer tissues, the expression of MTS1 and COX-2 assessed by relative fluorescence intensity were 0.84 and 10.54, respectively, and were 1.61 and 4.00 in corresponding para-cancer tissues, respectively. There was a significant difference between MTS1 and COX-2 expressions in cancer and corresponding para-cancer tissues (P <0.05). The differences of MTS1 and COX-2 expression of different ages, pathological types, tumor sizes or clinical stages of the breast cancer patients were not significant (P > 0.05). The MTS1 and COX-2 expressions were 1.12 and 5.94, respectively, in lymph node metastasis positive patients, and 0.79 and 13.05, respectively, in lymph node metastasis negative patients. The differences were significant (P <0.05).</p><p><b>CONCLUSION</b>The preliminary research results suggest that MTS1 and COX-2 gene expressions play fairly important role in tumorigenesis and progression of breast cancers. MTS1 and COX-2 protein expressions have correlation with lymph node metastasis. This study provides theoretical basis for use of COX-2 selective inhibitors in prevention and treatment for breast cancer patients.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Breast
/
Breast Neoplasms
/
Biomarkers, Tumor
/
Carcinoma, Ductal, Breast
/
Cyclin-Dependent Kinase Inhibitor p16
/
Cyclooxygenase 2
/
Flow Cytometry
/
Lymphatic Metastasis
/
Metabolism
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
Zh
Journal:
Chinese Journal of Oncology
Year:
2006
Type:
Article