Aldosterone/plasma renin activity ratio is a sensitive parameter for screening patients with primary aldosteronism / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 873-876, 2006.
Article
in Zh
| WPRIM
| ID: wpr-238500
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To screen primary aldosteronism cases with ARR (aldosterone/plasma renin activity, ARR) from patients with hypertension, and to evaluate the diagnosis value of ARR in primary aldosteronism cases and analysis the clinical characters of primary aldosteronism cases.</p><p><b>METHODS</b>Nine hundred and two patients with hypertension were collected, the plasma aldosterone concentration to plasma renin activity ratio were detected by radio-immunity method, after that, ARR were calculated. Retrospective analysis was made of clinical data in 126 primary aldosteronism cases, which ARR were over 25.</p><p><b>RESULTS</b>One hundred and twenty-six cases (14%) were diagnosed as primary aldosteronism, and of them, 49 cases had hypokalemia. 25 patients received surgical operation and the rate of efficiency and cure of surgery treatment were 100% and 48%, respectively. The rate of efficiency and cure of drug treatment was 89% and 24% respectively.</p><p><b>CONCLUSIONS</b>Primary aldosteronism affects over 10% of patients with hypertension in China. Patients with hypertension and most patients with treatment-resistant hypertension should undergo screening for primary aldosteronism with ARR. A high ARR is a positive screening test result, a finding that warrants confirmatory testing.</p>
Full text:
1
Index:
WPRIM
Main subject:
Potassium
/
Renin-Angiotensin System
/
Blood
/
Follow-Up Studies
/
Renin
/
Clinical Chemistry Tests
/
Diagnosis
/
Aldosterone
/
Hyperaldosteronism
/
Hypertension
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Cardiology
Year:
2006
Type:
Article