Gefitinib versus Erlotinib as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 446-449, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-239159
ABSTRACT
<p><b>OBJECTIVE</b>To compare the efficacy of the erlotinib versus gefitinib in the first-line treatment of patients with advanced EGFR mutation-positive NSCLC.</p><p><b>METHODS</b>Fifty patients with untreated advanced EGFR mutation- positive NSCLC were randomly divided into gefitinib group (n=27) and erlotinib group (n=23). The progression-free survival, objective response rate and disease control rate were evaluated to compare the efficacy of gefitinib and erlotinib.</p><p><b>RESULTS</b>There were no significant differences in the objective response rate (P=0.711) and disease control rate (P=0.861) between the two groups. The progression-free survival of gefitinib group and erlotinib group was 8.0 months and 10.0 months, respectively. The efficacy of the two drugs was similar (P=0.293).</p><p><b>CONCLUSION</b>There is no significant differences between gefitinib and erlotinib in the first-line treatment of patients with advanced EGFR mutation-positive NSCLC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quinazolines
/
Carcinoma, Non-Small-Cell Lung
/
Disease-Free Survival
/
Therapeutic Uses
/
Drug Therapy
/
ErbB Receptors
/
Erlotinib Hydrochloride
/
Lung Neoplasms
/
Metabolism
/
Mutation
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2015
Type:
Article
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