Levels of inflammation cytokines in patients with coronary heart disease and periodontal disease / 中华口腔医学杂志
Chinese Journal of Stomatology
; (12): 265-268, 2010.
Article
in Zh
| WPRIM
| ID: wpr-245210
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine the level of high-density lipoprotein cholesterol (HDL-C), serum C-reactive protein (CRP) and inflammation cytokines and investigate the concentration between periodontal disease and coronary heart disease (CHD).</p><p><b>METHODS</b>Sixty-six patients with CHD and chronic periodontitis [(C+P) group], forty-four with only CHD (C group), fifty-six with only chronic periodontitis (C group), and forty-three healthy controls (H group) were included in this study. The diagnosis of chronic periodontitis and CHD was based on accepted clinical criteria. Serum levels of HDL-C, CRP, IL-6, tumor necrosis factor (TNF)-alpha and IL-1beta were tested in all patients and controls.</p><p><b>RESULTS</b>The periodontal conditions of these four groups were significantly different (P<0.05). The clinical periodontal parameters [probing depth (PD), attachment loss (AL), and bleeding on probing (BOP)] in patients with (C+P) group, P group, C group and H group were [(4.55+/-0.85) mm, (3.78+/-0.34) mm, 69.6%], [(4.06+/-0.61) mm, (3.05+/-0.44) mm, 63.6%], [(1.85+/-0.67) mm, (1.26+/-0.39) mm, 20.5%], [(1.12+/-0.33) mm, (0.42+/-0.83) mm, 4.6%], respectively. The levels of HDL-C in H group, C group, P group and (C+P) group were (1.42+/-0.21), (1.22+/-0.18), (1.24+/-0.21) and (1.04+/-0.22) mmol/L, respectively. T compare with other three groups, the level of HDL-C in (C+P) group is the lowest. The levels of CRP, IL-6, TNF-alpha and IL-1beta in (C+P) group were significantly higher than other groups (P<0.05).</p><p><b>CONCLUSIONS</b>HDL-C, CRP, IL-6, TNF-alpha and IL-1beta may be associated with the pathogenesis of periodontitis and CHD. There may be a relationship between the two diseases.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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Blood
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C-Reactive Protein
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Periodontal Index
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Interleukin-6
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Tumor Necrosis Factor-alpha
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Periodontal Attachment Loss
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Coronary Disease
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Interleukin-1beta
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Chronic Periodontitis
Limits:
Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Stomatology
Year:
2010
Type:
Article