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Effect of donor bone marrow transfusion on renal allograft function in kidney transplant patients / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 285-289, 2010.
Article in Chinese | WPRIM | ID: wpr-259202
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of donor bone marrow transfusion on kidney function in renal allograft recipients.</p><p><b>METHODS</b>From May 1999 through May 2004, 74 cadaver renal transplant patients received postoperative donor bone marrow transfusion (DBMT group), the clinical outcomes were compared with 74 non-infused renal transplant recipients (control group). Both groups received the renal allograft from the same donor and were given equivalent immunosuppressant. The immunosuppressive regimen included tacrolimus/CiclosporinA, mycophenolate mofetil, and prednisolone maintenance. Patients were followed up for 24 to 108 months (mean 69.5 months).</p><p><b>RESULT</b>The serum creatinine concentrations of DBMT group at 1,2 and 3 y after operation were (105 + or - 23.9)micromol/L,(107.5 + or - 32.4) micromol/L and (115 + or - 26.6)micromol/L; those of control group were (114.7 + or - 28)micromol/L,(116.5 + or - 27.6)micromol/L and (125 + or - 32.6)micromol/L,respectively. Glomerular filtration rate (GFR) of DBMT group at 1,2 and 3 y after operation were (70.2 + or - 24.4)ml/min, (74.3 + or - 24.1)ml/min and (73.5 + or - 22.4)ml/min; those of control group were (62.4 + or - 15.8)ml/min, (63.9 + or - 18.7)ml/min and (61.9 + or - 20.3)ml/min. After 5 year-follow-up,the prevalence of proteinuria in DBMT group was 50% (37/74),that was 77% (57/74) in control group (P<0.01). Only 3/74 DBMT recipients had biopsy-proven chronic rejection, whereas 12/74 showed chronic rejection in the controls (P<0.05).</p><p><b>CONCLUSION</b>In kidney transplant recipients DBMC infusions may improve the long-term graft survival.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Tissue Donors / Blood / Follow-Up Studies / Bone Marrow Transplantation / Kidney Transplantation / Creatinine / Glomerular Filtration Rate / Kidney Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Tissue Donors / Blood / Follow-Up Studies / Bone Marrow Transplantation / Kidney Transplantation / Creatinine / Glomerular Filtration Rate / Kidney Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2010 Type: Article