Analysis of overexpression of vascular endothelial growth factor-C in patients with angioimmunoblastic T-cell lymphoma / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 664-666, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-262966
ABSTRACT
<p><b>OBJECTIVE</b>To explore the vascular endothelial growth factor-C (VEGF-C) expression and its clinical significance in malignant lymphoma.</p><p><b>METHODS</b>Lymphoma cells were isolated by laser microdissection. VEGF-C expression in lymphoma tissue and microdissected lymphoma cells was measured by realtime quantitative PCR. Meanwhile, vessel ultrastructure was identified by transmission electron microscopy.</p><p><b>RESULTS</b>Comparing with that in 8 patients with reactive lymphocyte hyperplasia, VEGF-C was overexpressed in angioimmunoblastic T-cell lymphoma, both in lymphoma tissue (n = 18, P = 0.0020) and in microdissected lymphoma cells (n = 10, P < 0.0001). Increased VEGF-C level was associated with bone marrow infiltration (P = 0.0039), skin involvement (P = 0.0046) and high-risk international prognostic index (P = 0.0302). In VEGF-C overexpressed cases, ultrastructural study showed dystrophic vessels, with swelling endothelial cells and absence of pericytes.</p><p><b>CONCLUSION</b>The value of VEGF-C expression might be a biomarker of disease progression in angioimmunoblastic T-cell lymphoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Lymphoma, T-Cell
/
Vascular Endothelial Growth Factor C
/
Immunoblastic Lymphadenopathy
/
Metabolism
/
Neovascularization, Pathologic
Type of study:
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2007
Type:
Article
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