Study on vitro release and transdermal behaviors of Yulian cataplasm / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the regularity of Yulian Cataplasm in vitro release and transdermal behaviors.</p><p><b>METHOD</b>Improved Franz diffusion devices was used with four index ingredients as evodiamine, rutaecarpine, palmatine and berberine that were determined by HPLC in one mobile phase.</p><p><b>RESULT</b>The release rates of evodiamine, rutaecarpine, palmatine and berberine were 0.0239, 0.0156, 0.0725, 0.8191 mg x cm(-2) x h(-1/2), respectivley. The transdermal rates of evodiamine, rutaecarpine, palmatine and berberine were 1.256, 1.0302, 2.8029, 20.919 microg x cm(-2) x h(-1), respectively.</p><p><b>CONCLUSION</b>The releasing process of all index is in accordance with Higuchi equation and the transdermal proccess is in accordance with zero-level equation.</p>