Forced running enhances neurogenesis in the hippocampal dentate gyrus of adult rats and improves learning ability / 生理学报
Acta Physiologica Sinica
;
(6): 415-420, 2006.
Article
in English
| WPRIM
| ID: wpr-265435
ABSTRACT
To investigate the effect of forced running in motor-driven wheel on neurogenesis in the hippocampal dentate gyrus (DG) of adult rats, 5-bromo-2-deoxyuridine (BrdU), a thymidine analog was applied to mark cell proliferation. Neuroepthelial stem cell protein (nestin) expression was used to identify neural stem/precursor cells. The BrdU- and nestin-positive cells were examined by immunohistochemical technique. The ability of learning was evaluated by Y-maze test to explore the functional role of the newborn cells in the DG after forced running. It was found that the number of BrdU- and nestin-positive cells in the DG in running groups was significantly increased compared to that in the control group (P<0.05). The effect of forced running on neurogenesis was intensity-dependent. In addition, an improvement of learning ability in Y-maze test was observed after forced running. These findings suggest that forced running in motor-driven wheel could enhance neurogenesis in the hippocampal DG of adult rats and improve learning ability.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physical Conditioning, Animal
/
Physiology
/
Running
/
Bromodeoxyuridine
/
Cell Survival
/
Rats, Sprague-Dawley
/
Maze Learning
/
Dentate Gyrus
/
Cell Biology
/
Nestin
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta Physiologica Sinica
Year:
2006
Type:
Article
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