A novel C27-steroidal glycoside sulfate from Liriope graminifolia / 药学学报
Acta Pharmaceutica Sinica
; (12): 619-623, 2012.
Article
in Zh
| WPRIM
| ID: wpr-276270
Responsible library:
WPRO
ABSTRACT
An unusual novel C27-steroidal glycoside sulfate was isolated from the underground organs of Liriope graminifolia (Linn.) Baker with three known compounds. Their chemical structures were determined by spectral analysis, including HR-MS, 1D and 2D NMR as (25S)-ruscogenin 1-sulfate-3-O-alpha-L-rhamnopyranoside (1), (25S)-ruscogenin 1-O-beta-D-xylopyranosyl-3-O-alpha-L-rhamnopyranoside (2), hesperidin (3), and 4', 7-dihydroxy-5-methoxyflavanone (4). Compound 1 has cytotoxic activities against K562 and HL60 cells with IC50 values of 18.6 microg x mL(-1) and 16.5 microg x mL(-1), respectively.
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Plants, Medicinal
/
Spirostans
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Drugs, Chinese Herbal
/
Chemistry
/
HL-60 Cells
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K562 Cells
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Inhibitory Concentration 50
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Liriope Plant
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Plant Tubers
Limits:
Humans
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article