Expression of fragile histidine triad (FHIT) protein and its significance in diagnosing classical Hodgkin lymphoma / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 289-291, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-277418
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of FHIT protein and its potential application in diagnosing classic Hodgkin lymphoma.</p><p><b>METHODS</b>Immunohistochemical study using EnVision method for FHIT tumor suppressor protein, hematopoietic stem cell markers CD133/AC133 and CD34, B-cell marker CD20, T-cell marker CD3 and oncoprotein c-erbB2 was performed on 33 cases of classic Hodgkin lymphoma.</p><p><b>RESULTS</b>Thirty-three of the Hodgkin lymphoma cases (90.9%) expressed FHIT protein. The antigen was mainly located in the cytoplasm, nucleus and membrane of classic Reed-Sternberg and Reed-Sternberg-like cells. Normal B and T lymphocytes, as well as their malignant counterparts, were negative for FHIT protein; whereas monocytes, histiocytes and dendritic cells were positive. All the cases studied were negative for CD133/AC133, CD34, CD3 and c-erbB-2. Two of the 33 cases showed positive staining for CD20 in some of the Reed-Sternberg cells.</p><p><b>CONCLUSION</b>The expression of FHIT protein can be used as a useful adjunct in diagnosing classic Hodgkin lymphoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptides
/
Hodgkin Disease
/
Immunohistochemistry
/
Glycoproteins
/
Biomarkers, Tumor
/
Antigens, CD
/
Cell Nucleus
/
Sensitivity and Specificity
/
Reed-Sternberg Cells
/
Acid Anhydride Hydrolases
Type of study:
Diagnostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2006
Type:
Article
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