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Prognostic factors for patients with cervical cancer treated with concurrent chemoradiotherapy: a retrospective analysis in a Japanese cohort / 부인종양
Journal of Gynecologic Oncology ; : 12-18, 2015.
Article in English | WPRIM | ID: wpr-27947
ABSTRACT

OBJECTIVE:

Concurrent chemoradiotherapy (CCRT) is the primary treatment for locally advanced cervical cancer. We studied prognostic factors for patients treated with CCRT.

METHODS:

We retrospectively reviewed records of 85 consecutive patients with cervical cancer who were treated with CCRT between 2002 and 2011, with external beam radiation therapy, intracavitary brachytherapy, and platinum-based chemotherapy. Survival data were analyzed with Kaplan-Meier methods and Cox proportional hazard models.

RESULTS:

Of the 85 patients, 69 patients (81%) had International Federation of Gynecology and Obstetrics (FIGO) stage III/IV disease; 25 patients (29%) had pelvic lymph node enlargement (based on magnetic resonance imaging), and 64 patients (75%) achieved clinical remission following treatment. Median maximum tumor diameter was 5.5 cm. The 3- and 5-year overall survival rates were 60.3% and 55.5%, respectively. Cox regression analysis showed tumor diameter >6 cm (hazard ratio [HR], 2.3; 95% confidence interval [CI], 1.2 to 4.6), pelvic lymph node enlargement (HR, 2.2; 95% CI, 1.1 to 4.5), and distant metastasis (HR, 10.0; 95% CI, 3.7 to 27.0) were significantly and independently related to poor outcomes.

CONCLUSION:

New treatment strategies should be considered for locally advanced cervical cancers with tumors >6 cm and radiologically enlarged pelvic lymph nodes.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Brachytherapy / Proportional Hazards Models / Uterine Cervical Neoplasms / Retrospective Studies / Treatment Outcome / Kaplan-Meier Estimate / Chemoradiotherapy / Lymphatic Metastasis Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans Language: English Journal: Journal of Gynecologic Oncology Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Brachytherapy / Proportional Hazards Models / Uterine Cervical Neoplasms / Retrospective Studies / Treatment Outcome / Kaplan-Meier Estimate / Chemoradiotherapy / Lymphatic Metastasis Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans Language: English Journal: Journal of Gynecologic Oncology Year: 2015 Type: Article