Application of carbon nanoparticles in the laparoscopic sentinel lymph node detection in patients with cervical cancer / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 150-154, 2013.
Article
in Zh
| WPRIM
| ID: wpr-284286
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the role of laparoscopic sentinel lymph node(SLN) detection with carbon nanoparticles tracer in cervical carcinoma.</p><p><b>METHODS</b>Totally 21 patients with confirmed early cervical cancer were enrolled in this study.Before laparoscopic extended hysterectomy and pelvic lymphadenoetomy(and para-aortic lymphadenoectomy) , they were injected with carbon nanoparticles suspension injection tracer from cervical neck before surgery. The black-staining lymph nodes were cut as SLN under the laparoscope for routine pathological examination.</p><p><b>RESULTS</b>Of these 21 patients, at least one SLN was successfully detected in 20 patients(95.24%) , and a total of 158 SLNs were detected.The conventional pathology results suggested that 5 patients(23.81%) had positive lymph nodes(n=16, including 14 in 4 patients) . The new approach showed a sensitivity of 80.0%(4/5) , accuracy of 100.0%(20/20) , and negative predictive value of 100.0%(16/16) for SLN detection.</p><p><b>CONCLUSION</b>Laparoscopic SLN detection with carbon nanoparticles tracer is a relative safe and sensitive method for in cervical carcinoma.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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Uterine Cervical Neoplasms
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Predictive Value of Tests
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Sensitivity and Specificity
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Laparoscopy
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Sentinel Lymph Node Biopsy
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Nanoparticles
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Lymphatic Metastasis
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Methods
Type of study:
Diagnostic_studies
Limits:
Female
/
Humans
Language:
Zh
Journal:
Acta Academiae Medicinae Sinicae
Year:
2013
Type:
Article