Changes of gap junction in penile cavernous smooth muscle cells of hypertensive rats / 中华男科学杂志
National Journal of Andrology
;
(12): 1010-1013, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-289088
ABSTRACT
<p><b>OBJECTIVE</b>To compare the changes of the intercellular conjunction in penile cavernous tissues between spontaneously hypertensive rats (SHR) and normotensive ones, and to study the relation of blood pressure with erectile function.</p><p><b>METHODS</b>After apomorphine (APO) injection, we observed penile erections in SHR (SHR group, n=5) and Wistar-Kyoto rats (WKY group, n=5), studied the ultrastructure of the cell-to-cell conjunction between the penile cavernous smooth muscle cells with a transmission electrical microscope, and examined the expression of mRNA and Connexin 43 protein by RT-PCR and immunohistochemistry.</p><p><b>RESULTS</b>The erectile frequency in the SHR group was significantly lower than in the WKY group. The smooth muscle cells were decreased and the collagen fibers between the smooth muscle cells were increased in the SHR group. The expression of mRNA and Connexin 43 protein in the cavernous tissues was significantly lower in the SHR group than in the WKY group (P < 0.05).</p><p><b>CONCLUSION</b>Hypertension affects penile erection, and the pathological changes of the cell-to-cell conjunction between the penile cavernous smooth muscle cells may be one of the important mechanisms of erectile dysfunction associated with hypertension.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Penis
/
Pharmacology
/
Physiology
/
Rats, Inbred SHR
/
Rats, Inbred WKY
/
Penile Erection
/
RNA, Messenger
/
Immunohistochemistry
/
Apomorphine
Limits:
Animals
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS