Effects of r-hGH replacement therapy on glucose and lipid metabolism and thyroid function in children with idiopathic short stature / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 1236-1240, 2014.
Article
in Zh
| WPRIM
| ID: wpr-289495
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of recombinant human growth hormone (r-hGH) replacement therapy on glucose and lipid metabolism and thyroid function in children with idiopathic short stature (ISS).</p><p><b>METHODS</b>Forty-seven ISS children with a mean age of 10±3 years treated between January 2009 and January 2013 were enrolled. All children underwent r-hGH replacement therapy for 3-24 months and were followed up once every 3 months. Fasting blood glucose (FBG), insulin (INS), blood lipids and thyroid function were measured before treatment and after 0-1 and 1-2 years of treatment.</p><p><b>RESULTS</b>After treatment with r-hGH, there were no significant changes in FBG, INS, insulin sensitivity index (ISI), and FBG/INS ratio (FGIR), but the FGIR showed a declining trend. The percentage of patients with FGIR<7 (a marker of insulin resistance) was 13% before treatment compared to 18% 1-2 years after treatment. The atherosclerosis index decreased after r-hGH treatment, but there were no significant changes in total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and BMI. Furthermore, no significant change in thyroid function was observed after r-hGH therapy.</p><p><b>CONCLUSIONS</b>r-hGH therapy can improve lipid metabolism, without significant impacts on thyroid function, FBG and INS. It seems to be a safe and reliable therapy for children with ISS. However, this therapy possibly reduces insulin sensitivity.</p>
Full text:
1
Index:
WPRIM
Main subject:
Thyroid Gland
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Blood
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Blood Glucose
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Human Growth Hormone
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Hormone Replacement Therapy
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Therapeutic Uses
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Drug Therapy
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Lipid Metabolism
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Glucose
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Growth Disorders
Limits:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2014
Type:
Article