Comparative pharmacokinetic studies of borneol in brain and plasma of stroke or sham-operated rats after administration of Xingnaojing / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3763-3767, 2013.
Article
in Zh
| WPRIM
| ID: wpr-291288
Responsible library:
WPRO
ABSTRACT
In order to research the pharmacokinetic characteristic of borneol in plasma and brain of stroke rats given XNJ and investigate the influence of stroke on the borneol passing through the blood-brain barrier, this study established the GC to determine the borneol in brain and blood, and made the stroke mode rats by middle carotid artery occlusion (MCAO) and set sham-operated group. After oral administration of Xingnaojing (XNJ) suspension, their blood and brain were collected at different time and detected by GC. The data was analysed by Kinetica. Results showed that in stroke group, the Cmax and AUC0-t of brain and plasma are (1.82 +/- 0.825), (1.35 +/- 0.43) mg x L(-1) and (123.39 +/- 55.82), (87.91 +/- 39.81) mg x L(-1) x min, Te (brain/blood drug ratio) was 70.93%; those pharmacokinetic values were larger than in sham-operated group. We can conclude that the pathological state of stroke can increase the amount of borneol permeating into brain.
Full text:
1
Index:
WPRIM
Main subject:
Plasma
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Camphanes
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Brain
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Drugs, Chinese Herbal
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Pharmacokinetics
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Chemistry
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Administration, Oral
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Stroke
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Drug Therapy
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Metabolism
Limits:
Animals
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Humans
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Male
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2013
Type:
Article