Influence of assisted reproduction technologies on genomic imprinting of embryos and offspring / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 462-465, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-291753
ABSTRACT
Assisted reproduction technologies (ART) include controlled ovarian hyperstimulation, in vitro fertilization-embryo transfer, intracytoplasmic sperm injection, in vitro maturation of oocytes, pre-implantation genetic diagnosis, etc. They have been used for the treatment of impaired fertility but may damage the health of offspring. The ART procedures may alter the epigenetic status of these offspring and DNA methylation may be a crucial mechanism. This paper summarizes epigenetic alterations in ART embryos and offspring, and discusses the risks.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Fertilization in Vitro
/
Genomic Imprinting
/
DNA Methylation
/
Preimplantation Diagnosis
/
Embryo, Mammalian
/
Metabolism
Type of study:
Diagnostic study
Limits:
Animals
/
Female
/
Humans
/
Pregnancy
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2014
Type:
Article
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