Aging reduces contents of endogenous CO, cAMP and cGMP in rat penile tissues / 中华男科学杂志
National Journal of Andrology
; (12): 122-125, 2009.
Article
in Zh
| WPRIM
| ID: wpr-292413
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship of aging with the changes of endogenous carbon monoxide (CO), cGMP and cAMP contents in the penile tissues of rats.</p><p><b>METHODS</b>Twenty-four male rats were equally divided into an 8-month, a 16-month and a 24-month group, and their penile erection was detected by injecting apomorphine, their penile cavernous body harvested, and the contents of CO, cAPM and cGMP detected by improved dual wavelength spectrophotometry.</p><p><b>RESULTS</b>The contents of CO, cAPM and cGMP were reduced with the increase of age, with statistically significant differences between the three age groups (P < 0.01).</p><p><b>CONCLUSION</b>Aging significantly decreased the contents of CO, cAMP and cGMP in the penile tissues of the rats, which suggests that aging might play an important role in erectile dysfunction.</p>
Full text:
1
Index:
WPRIM
Main subject:
Penis
/
Physiology
/
Aging
/
Carbon Monoxide
/
Rats, Wistar
/
Cyclic AMP
/
Cyclic GMP
/
Metabolism
Limits:
Animals
Language:
Zh
Journal:
National Journal of Andrology
Year:
2009
Type:
Article