Raf/MEK/ERK1/2 signaling pathway and penile erection / 中华男科学杂志
National Journal of Andrology
; (12): 354-358, 2010.
Article
in Zh
| WPRIM
| ID: wpr-295059
Responsible library:
WPRO
ABSTRACT
Penile erection is regulated by the relaxation of corpus cavernosum smooth muscle cells (CCSMCs). It has been recognized that the Ras/MEK/ERK1/2 signaling pathway is closely related to the functions of CCSMCs and endothelial cells, and it is involved in the regulation of penile erection, mainly via phosphorylation of NO synthase. ERK1/2 phosphorylates, inhibits eNOS activity, and thus reduces the relaxation of CCSMCs and penile erection. But the site of phosphorylation is not yet clear. In CCSMCs and endothelial cells, the ERK1/2 pathway interacts with other cascades and regulates the erectile function of the penis. This article presents an overview of the researches on the ERK1/2 signaling cascade, its regulatory role and its interaction with other signaling pathways in penile erection.
Full text:
1
Index:
WPRIM
Main subject:
Penis
/
Physiology
/
Penile Erection
/
Signal Transduction
/
Raf Kinases
/
Mitogen-Activated Protein Kinase 3
/
Metabolism
Limits:
Humans
/
Male
Language:
Zh
Journal:
National Journal of Andrology
Year:
2010
Type:
Article