Cardiovascular benefits of vitamin D / 生理学报
Acta Physiologica Sinica
;
(6): 30-36, 2014.
Article
in English
| WPRIM
| ID: wpr-297519
ABSTRACT
Vitamin D is essential for maintaining calcium and phosphate homeostasis, and vitamin D analogues have been prescribed to treat osteoporosis and hyperparathyroidism. Emerging evidence suggests that cardiovascular and chronic kidney diseases are closely associated with vitamin D deficiency resulting from either decreased sunshine exposure or inadequate intake. Vitamin D is through stimulating vitamin D receptor to form a transcriptional complex with cofactors to modulate approximately 3% gene transcription. For example, renin, matrix metalloprotease, and tumor necrosis factor-α are regulated by vitamin D. Both experimental and clinical studies support the health benefits of vitamin D in the cardiovascular system, and such benefits include protecting cardiac function, lowering blood pressure, improving endothelial function, inhibiting oxidative stress, and reducing the activity of renin-angiotensin system. This article will briefly review the cardiovascular benefits of vitamin D and its bioactive analogues and discuss the novel cellular and molecular mechanisms accounting for cardiovascular protection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Renin-Angiotensin System
/
Vitamin D
/
Vitamin D Deficiency
/
Blood Pressure
/
Endothelium, Vascular
/
Cardiovascular Diseases
/
Cardiovascular Physiological Phenomena
/
Calcium
/
Receptors, Calcitriol
Limits:
Humans
Language:
English
Journal:
Acta Physiologica Sinica
Year:
2014
Type:
Article
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