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Cardiovascular benefits of vitamin D / 生理学报
Acta Physiologica Sinica ; (6): 30-36, 2014.
Article in English | WPRIM | ID: wpr-297519
ABSTRACT
Vitamin D is essential for maintaining calcium and phosphate homeostasis, and vitamin D analogues have been prescribed to treat osteoporosis and hyperparathyroidism. Emerging evidence suggests that cardiovascular and chronic kidney diseases are closely associated with vitamin D deficiency resulting from either decreased sunshine exposure or inadequate intake. Vitamin D is through stimulating vitamin D receptor to form a transcriptional complex with cofactors to modulate approximately 3% gene transcription. For example, renin, matrix metalloprotease, and tumor necrosis factor-α are regulated by vitamin D. Both experimental and clinical studies support the health benefits of vitamin D in the cardiovascular system, and such benefits include protecting cardiac function, lowering blood pressure, improving endothelial function, inhibiting oxidative stress, and reducing the activity of renin-angiotensin system. This article will briefly review the cardiovascular benefits of vitamin D and its bioactive analogues and discuss the novel cellular and molecular mechanisms accounting for cardiovascular protection.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Renin-Angiotensin System / Vitamin D / Vitamin D Deficiency / Blood Pressure / Endothelium, Vascular / Cardiovascular Diseases / Cardiovascular Physiological Phenomena / Calcium / Receptors, Calcitriol Limits: Humans Language: English Journal: Acta Physiologica Sinica Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Renin-Angiotensin System / Vitamin D / Vitamin D Deficiency / Blood Pressure / Endothelium, Vascular / Cardiovascular Diseases / Cardiovascular Physiological Phenomena / Calcium / Receptors, Calcitriol Limits: Humans Language: English Journal: Acta Physiologica Sinica Year: 2014 Type: Article