Analysis of antibiotics treatment in 86 cases of liver transplant recipients / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 852-855, 2009.
Article
in Zh
| WPRIM
| ID: wpr-306629
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the characteristic of bacterial infections, and the relationship between antibiotics treatment and bacterial infections after liver transplantation, and to prevent antibiotic-resistant bacterial infections.</p><p><b>METHODS</b>86 liver transplant recipients were retrospected. Different indexes including limited daily dose, the frequency of medication, drug use index were used to evaluate the rationality of the use of antibiotics, three-dimensional test was used to explore extended-spectrum beta-lactamase and AmpC enzyme of Gram-negative bacteria.</p><p><b>RESULTS</b>The major pathogens of infection after liver transplantation were Enterococcus faecalis, Enterobacter cloacae, fungi and E. coli. Pre-operative antibiotic utilization rate was 83.7%, it was mainly a single use of antibiotics; After- operative antibiotic usage was 100.0%, it was mainly joint use of two or three antibiotics; The top 3 antibiotics used were cephalosporins, the combined enzyme inhibitors and penicillin. Antibiotics with drug utilization index (DUI) more than 1.1 included ampicillin and Lalin proxy. 43.3% and 31.8% of Gram -Negative bacteria produced ESBLs and AmpC, respectively, while 21.3% Gram -Negative bacteria produced two enzymes.</p><p><b>CONCLUSION</b>There is high incidence of bacterial infections after liver transplantation. The use of antibiotics is high dose, high-frequency and reasonable; High resistance of bacterial infections was prone to develop and the prevention of the high resistance of bacterial infections is very important.</p>
Full text:
1
Index:
WPRIM
Main subject:
Postoperative Complications
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Bacterial Infections
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Beta-Lactamases
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Microbial Sensitivity Tests
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Epidemiology
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Retrospective Studies
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Liver Transplantation
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Drug Resistance, Bacterial
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Therapeutic Uses
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Drug Therapy
Type of study:
Observational_studies
Limits:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Language:
Zh
Journal:
Chinese Journal of Hepatology
Year:
2009
Type:
Article