Diterpenoid alkaloids from roots of Aconitum recemulosum and their inhibitory effects on PAF-induced platelet aggregation / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1935-1937, 2009.
Article
in Zh
| WPRIM
| ID: wpr-307671
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study diterpenoid alkaloids from the roots of Aconitum recemulosum, and their inhibitory effects on PAF-induced platelet aggregation.</p><p><b>METHOD</b>The root of A. recemulosum was extracted with 95% EtOH. The total alkaloids extracted were isolated and purified by several kinds of column chromatography over silica gel, RP-18, and Sephadex LH-20, and identified based on spectral analysis. And the inhibitory effects of isolated compounds on PAF-induced platelet aggregation were detected.</p><p><b>RESULT</b>Five alkaloids were isolated and identified as sachaconitine (1), 14-acetylsachaconitine (2), hemsleyanine C (3), circinasine A (4), and talatisamine (5). The results showed compounds 1 and 2 have moderate inhibition effect on PAF.</p><p><b>CONCLUSION</b>Compounds 1-5 were firstly isolated from this plant. Furthermore, compounds 1 and 2 possessed moderate inhibitory effects on PAF-induced platelet aggregation.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Coagulants
/
Plant Extracts
/
Chemistry
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Platelet Aggregation
/
Plant Roots
/
Aconitum
/
Diterpenes
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Alkaloids
Limits:
Humans
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article