Synthesis and characterization of thermosensitive hydrogel based on PEG-PCL-PEG block copolymers / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 1121-1125, 2008.
Article
in Zh
| WPRIM
| ID: wpr-318201
Responsible library:
WPRO
ABSTRACT
In this paper, a series of low-molecular-weight PEG-PCL-PEG triblock copolymers were successfully synthesized by ring-opening polymerization method, and were characterized using 1H-NMR and FTIR. The aqueous solution displayed specific thermosensitive gel-sol transition when the concentration was above corresponding critical gel concentration (CGC). The gel-sol phase diagram was recorded using test tube-inverting method, which was depended on the hydrophilic/hydrophobic balance in macromolecular structure, as well as heating history. As a result, the gel-sol transition temperature range could be altered, which might be very useful for its application as injectable drug delivery system.
Full text:
1
Index:
WPRIM
Main subject:
Polyesters
/
Polyethylene Glycols
/
Temperature
/
Biocompatible Materials
/
Drug Carriers
/
Chemistry
/
Drug Delivery Systems
/
Spectroscopy, Fourier Transform Infrared
/
Hydrogel, Polyethylene Glycol Dimethacrylate
Language:
Zh
Journal:
Journal of Biomedical Engineering
Year:
2008
Type:
Article