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Synthesis and characterization of thermosensitive hydrogel based on PEG-PCL-PEG block copolymers / 生物医学工程学杂志
Journal of Biomedical Engineering ; (6): 1121-1125, 2008.
Article in Zh | WPRIM | ID: wpr-318201
Responsible library: WPRO
ABSTRACT
In this paper, a series of low-molecular-weight PEG-PCL-PEG triblock copolymers were successfully synthesized by ring-opening polymerization method, and were characterized using 1H-NMR and FTIR. The aqueous solution displayed specific thermosensitive gel-sol transition when the concentration was above corresponding critical gel concentration (CGC). The gel-sol phase diagram was recorded using test tube-inverting method, which was depended on the hydrophilic/hydrophobic balance in macromolecular structure, as well as heating history. As a result, the gel-sol transition temperature range could be altered, which might be very useful for its application as injectable drug delivery system.
Subject(s)
Full text: 1 Index: WPRIM Main subject: Polyesters / Polyethylene Glycols / Temperature / Biocompatible Materials / Drug Carriers / Chemistry / Drug Delivery Systems / Spectroscopy, Fourier Transform Infrared / Hydrogel, Polyethylene Glycol Dimethacrylate Language: Zh Journal: Journal of Biomedical Engineering Year: 2008 Type: Article
Full text: 1 Index: WPRIM Main subject: Polyesters / Polyethylene Glycols / Temperature / Biocompatible Materials / Drug Carriers / Chemistry / Drug Delivery Systems / Spectroscopy, Fourier Transform Infrared / Hydrogel, Polyethylene Glycol Dimethacrylate Language: Zh Journal: Journal of Biomedical Engineering Year: 2008 Type: Article