Your browser doesn't support javascript.
loading
Effect of isopropyl 3-(3,4-dihydroxyphenyl) -2-hydroxypropanoate on rat pulmonary artery smooth muscle / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 2942-2945, 2008.
Article in Chinese | WPRIM | ID: wpr-324770
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of isopropyl 3-(3,4-dihydroxyphenyl)-2- hydroxypropanoate on vascular smooth muscle.</p><p><b>METHOD</b>Isolated rat pulmonary artery was perfused and the tension of the vessel was measured, the effect of isopropyl 3-(3, 4-dihydroxyphenyl)-2-hydroxypropanoate on the pulmonary artery precontracted by noradrenaline (NE) and concentration-response curves of 5-hydroxytryptamine (5-HT), endothelin-1 (ET-1), U46619 and KCl was also observed.</p><p><b>RESULT</b>Isopropyl 3-(3,4-dihydroxyphenyl) -2-hydroxypropanoate exerted relaxation effect on the endothelium-intact artery precontracted by NE in a concentration-dependent manner, which was inhibited with denuded endothelium. The right-shift of the concentration-response curves of 5-HT, ET-1, U46619 and KCl.</p><p><b>CONCLUSION</b>Isopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate have relaxation action on rat pulmonary artery in the way of endothelium-dependance, the mechanism of relaxation action by isopropyl 3-(3,4-dihydroxyphenyl) -2-hydroxypropanoate may be related to calcium channels.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Physiology / Propionates / Pulmonary Artery / In Vitro Techniques / Rats, Sprague-Dawley / Muscle Contraction / Muscle, Smooth, Vascular Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2008 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Physiology / Propionates / Pulmonary Artery / In Vitro Techniques / Rats, Sprague-Dawley / Muscle Contraction / Muscle, Smooth, Vascular Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2008 Type: Article