Serum anti-titin antibody in patients with myasthenia gravis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 725-727, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-326998
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical significance of serum anti-titin antibody level in the diagnosis of myasthenia gravis (MG) with thymoma.</p><p><b>METHOD</b>The serum anti-titin antibody was analysed by ELISA method in 40 cases of health control group, 90 cases of MG, 17 cases of MG with thymoma and 7 cases of no-MG thymoma. The positive rate was compared among these groups.</p><p><b>RESULTS</b>The positive rate of anti-titin antibody was significantly higher in MG with thymoma patients than MG patients (94% and 3%, P < 0.01). According to the Osserman's classification, anti-titin antibody was present mostly in patients (43%) in IV stage, and also present in 2 cases of 7 who with no-MG thymoma.</p><p><b>CONCLUSION</b>Serum anti-titin antibody test is helpful in the diagnosis of MG with thymoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Kinases
/
Thymoma
/
Thymus Neoplasms
/
Blood
/
Enzyme-Linked Immunosorbent Assay
/
Diagnosis
/
Allergy and Immunology
/
Connectin
/
Antibodies
/
Muscle Proteins
Type of study:
Diagnostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2003
Type:
Article
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