The relationship between haplotypes of multilocus markers and ankylosing spondylitis / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 312-315, 2004.
Article
in Zh
| WPRIM
| ID: wpr-328888
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between haplotypes of multilocus markers and ankylosing spondylitis (AS).</p><p><b>METHODS</b>Five families with AS were recruited from Shanghai area. Eleven microsatellite markers around D6S276 were analyzed by Linkage package and by Cyrillic package.</p><p><b>RESULTS</b>Fine linkage analysis showed the significant Lod score values with D6S276 was 3.8821, Lod score values with D6S1691 and D6S1618 near D6S276 were larger than 1.5. The crossover value in 5 pedigrees was 14%. The haplotype analysis showed that the regions between D6S1691 and D6S1618 were associated with AS.</p><p><b>CONCLUSION</b>The regions of D6S1691-D6S276-D6S1618 may harbor a susceptible gene of AS. The specific haplotypes of different pedigrees may play an important role in the presymptomatic diagnosis for AS.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pedigree
/
Spondylitis, Ankylosing
/
Haplotypes
/
Linkage Disequilibrium
/
Genetics
Limits:
Female
/
Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2004
Type:
Article