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Next-generation sequencing and its application in acute myeloid leukemia and myelodysplastic syndrome / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1545-1549, 2011.
Article in Chinese | WPRIM | ID: wpr-331036
ABSTRACT
The next-generation sequencing (NGS), as the most practical and reliable method, has replaced the classical Sanger sequencing to help scientists to discover the genetics secrets of human tumor diseases. With the technique development, the whole genome sequencing will be no longer out of reach. Recently, some scientists used the NGS in the research of hematological malignancies and pushed the progress of the whole genome sequencing in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) actively in order to find out the pathogenesis of some hematological malignancies. The NGS and the application of the whole genome sequencing, the exome sequencing, the transcriptome sequencing in AML and MDS are reviewed in this article.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Myelodysplastic Syndromes / Base Sequence / Leukemia, Myeloid, Acute / Genome, Human / Sequence Analysis / Hematologic Neoplasms / Genetics / Methods Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Myelodysplastic Syndromes / Base Sequence / Leukemia, Myeloid, Acute / Genome, Human / Sequence Analysis / Hematologic Neoplasms / Genetics / Methods Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2011 Type: Article