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Optimized quantitative angiographic and intravascular ultrasound parameters predicting the functional significance of single de novo lesions in the left anterior descending artery / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 4249-4253, 2012.
Article in English | WPRIM | ID: wpr-339862
ABSTRACT
<p><b>BACKGROUND</b>The correlation between angiographic or intravascular ultrasound (IVUS) variables and fractional flow reserve (FFR) in patients with single left anterior descending artery (LAD) lesion has not been studied. The current study aimed at determining the best cutoff value of angiographic and IVUS parameters for defining FFR < 0.80 in patients with LAD lesion.</p><p><b>METHODS</b>Quantitative coronary analysis, IVUS and FFR measurements were undergone in 169 patients with single LAD lesion. The best angiographic and IVUS cutoff value and their predictive value for FFR < 0.80 were compared using area under the receiver-operator characteristic curve (AUC) in overall patients or in subgroups stratified by lesion sites.</p><p><b>RESULTS</b>FFR < 0.80 was found in 99 lesions (58.6%). Minimal lumen area (MLA), and plaque burden (PB) were two predictors of FFR < 0.80. Lesion length had less value in predicting FFR < 0.80. The cutoff value of PB and MLA for FFR < 0.80 was 75.4% and 3.03 mm(2). MLA and PB had similar high diagnostic value for proximal (cutoff value 3.04 mm(2) and 76.5%) and distal LAD lesion (2.82 mm(2) and 80.6%). Combination of MLA (2.82 mm(2)) and PB (80.6%) had increased diagnostic value for distal LAD lesion.</p><p><b>CONCLUSIONS</b>MLA and plaque burden had equivalent diagnostic value for FFR < 0.80 when lesion localized in LAD. The predictive value of combination of MLA and plaque burden for distal LAD lesion was strengthened.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Coronary Artery Disease / Diagnostic Imaging / Coronary Angiography / Ultrasonography, Interventional / Coronary Vessels / Plaque, Atherosclerotic / Methods Type of study: Diagnostic study / Prognostic study Limits: Female / Humans / Male Language: English Journal: Chinese Medical Journal Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Coronary Artery Disease / Diagnostic Imaging / Coronary Angiography / Ultrasonography, Interventional / Coronary Vessels / Plaque, Atherosclerotic / Methods Type of study: Diagnostic study / Prognostic study Limits: Female / Humans / Male Language: English Journal: Chinese Medical Journal Year: 2012 Type: Article