Prediction of lymph node metastasis with binary logistic regression in gastric carcinoma / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 436-439, 2005.
Article
in Zh
| WPRIM
| ID: wpr-345159
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate more specific markers to predict the lymph node metastasis in gastric carcinoma.</p><p><b>METHODS</b>The expression of heparanase mRNA was detected by reverse transcription polymerase chain reaction (RT-PCR) in 43 cases with gastric cancer. The expressions of CD44V6, MMP-7, nm23 and syndecan-1 protein were examined by streptavidin-peroxidase (SP) two-step method. Clinicopathological features influencing lymphatic metastasis such as age,sex,tumor size,tumor location, Borrmann classification, histological type, differentiation and serosal infiltration were also analyzed.</p><p><b>RESULTS</b>Twenty-seven cases (62.8%) in 43 gastric cancer patients had lymphatic metastasis. The incidence of metastatic lymph nodes was(36.3 +/- 30.8)%. The median incidence was 19%. Univariate analysis showed that tumor size, serosal infiltration, expressions of heparanase mRNA, CD44V6, nm23 and syndecan-1 protein were risk factors for lymph node metastasis in gastric carcinoma. Multivariate analysis showed expressions of nm23 and syndecan-1 protein, serosal infiltration were independent factors for lymph node metastasis.</p><p><b>CONCLUSION</b>Gastric cancer with serosal infiltration, positive expressions of nm23 and syndecan-1 has greater possibility of lymph node metastasis.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Prognosis
/
Stomach Neoplasms
/
RNA, Messenger
/
Biomarkers, Tumor
/
Logistic Models
/
Reverse Transcriptase Polymerase Chain Reaction
/
Syndecan-1
/
NM23 Nucleoside Diphosphate Kinases
/
Genetics
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2005
Type:
Article