Association between pancreatic cancer risk and the interaction of U2AF65 gene polymorphisms and smoking / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 710-713, 2014.
Article
in Zh
| WPRIM
| ID: wpr-348588
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine the association between U2 small nuclear ribonucleoprotein auxiliary factor 35/65 (U2AF35 and U2AF65) and pancreatic cancer (PC).</p><p><b>METHODS</b>A two-stage analysis case-control study was conducted. Four candidate tag single nucleotide polymorphisms (tagSNPs) were genotyped by Taqman Openarray assay in a screening population living in Central China (298 PC cases and 525 controls). Thereafter, rs310445 in U2AF65 was genotyped by TaqMan real-time polymerase chain reaction (RT-PCR) in a validation Chinese Han population from Beijing (413 cases and 557 controls).</p><p><b>RESULTS</b>rs310445 in U2AF65 gene was significantly associated with PC in both screened population and combined population. Subjects with C allele had a higher risk of PC compared to those with the TT genotype, with OR of 1.31 (95%CI:1.07-1.60, P = 0.010) for the combined population. A synergic effect of smoking and C allele of rs310445 was also observed in the combined population, with Synergic Index of 2.08 (95% CI:1.37-2.78) in the combined population.</p><p><b>CONCLUSION</b>Our findings suggested the interaction between smoking and U2AF65 might play a role in PC. These findings should be confirmed by further independently large-scale population studies.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pancreatic Neoplasms
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Ribonucleoproteins
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Nuclear Proteins
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Smoking
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Case-Control Studies
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Risk Factors
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Polymorphism, Single Nucleotide
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Splicing Factor U2AF
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Genetics
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Genotype
Type of study:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limits:
Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Epidemiology
Year:
2014
Type:
Article