Lupus erythematosus panniculitis: clinical and histopathological analysis of 22 cases / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 525-528, 2011.
Article
in Zh
| WPRIM
| ID: wpr-352994
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the clinical and histopathological manifestations, therapy and prognosis of lupus erythematosus panniculitis (LEP).</p><p><b>METHOD</b>We retrospectively reviewed the clinical data and histopathological features of 22 cases of LEP diagnosed at Peking Union Medical College Hospital from January 2008 to February 2010.</p><p><b>RESULTS</b>The lesions appeared as atrophy, erythema, subcutaneous nodules, infiltrated erythema, and ulceration over the scalp, face, upper limbs, and buttock. Histopathological features were lobular panniculitis in the subcutaneous fat; sometimes septal panniculitis could be seen. Hydroxychloroquine sulfate and corticosteroid were effective treatment; most patients responded well to the treatment, while a few experienced recurrence when the treatment tapped or discontinued.</p><p><b>CONCLUSIONS</b>LEP is a rare cutaneous variant of lupus erythematosus. The diagnosis of LEP is mainly based on clinical findings and pathological features. Hydroxychloroquine and low- and middle-dose corticosteroid are effective for the treatment of LEP.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Prognosis
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Panniculitis, Lupus Erythematosus
/
Retrospective Studies
/
Drug Therapy
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adult
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Aged
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Female
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Humans
/
Male
Language:
Zh
Journal:
Acta Academiae Medicinae Sinicae
Year:
2011
Type:
Article