Post-transcriptional protein modification of Gata4 / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 800-803, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-353861
ABSTRACT
Gata4 is an important transcription factor in heart development. Gata4 post-transcriptional protein modification regulates transcriptional activity and DNA binding, which in turn affects expression of downstream genes and transcription factors, differentiation of embryonic stem cells and cardiogenesis. This article summarizes the effect of post-transcriptional protein modification on transcriptional activity of Gata4 and the relationship between this effect and congenital heart disease. It was shown that acetylation, phosphorylation and SUMOylation upregulate transcriptional activity, DNA binding, downstream gene expression and embryonic stem cell differentiation. On the other hand, methylation and deacetylation downregulate Gata4 transcriptional activity. Post-transcriptional protein modification of Gata4 is very important in clinical research on congenital and other heart diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphorylation
/
Acetylation
/
Chemistry
/
Protein Processing, Post-Translational
/
GATA4 Transcription Factor
/
Sumoylation
/
Genetics
/
Metabolism
/
Methylation
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2012
Type:
Article
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