Serum CPK-isoform after Cardiopulmonary Bypass / 日本心臓血管外科学会雑誌
Japanese Journal of Cardiovascular Surgery
;
: 552-555, 1992.
Article
in Japanese
| WPRIM
| ID: wpr-365867
ABSTRACT
CPK-MM, one of the CPK-isozyme, is divided into the three subbands (isoform) MMa, MMb, MMc. It has reported that in acute myocardial infarction serum MMa and MMa/MMc increased earlier than other myocardial intracellular enzyme, such as CPK-MB. In this study, we measured serum CPK, CPK isozyme, and CPK isoforms during and after open heart surgery and examined whether CPK isoforms would serve as a marker for myocardial damage during open heart surgery. CPK-MB peaked at 153.3±85.1IU six hours after cardiopulmonary bypass (CPB) was taken off and subsequently decreased. On the other hand, MMa/MMc peaked at 5.6±2.2 immediately after CPB was taken off. Moreover, we found that there was a statistically significant positive correlation (<i>Y</i>=24.46<i>X</i>+16.68, <i>r</i>=0.63, <i>p</i><0.05) between MMa/MMc immediately after CPB was taken off and CPK-MB six hours after CPB was taken off. The maximum value of CPK-MB correlates with the degree of myocardial damage. Therfore, it is reasonable to suggest that the maximum value of MMa/MMc immediately after CPB is taken off also correlates with the degree of myocardial damage. We concluded that serum CPK isoform, especially MMa/MMc served as a marker to estimates the degree of myocardial damage in open heart surgery at an early stage.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Japanese
Journal:
Japanese Journal of Cardiovascular Surgery
Year:
1992
Type:
Article
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