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Prognostic Significance of p53, mTOR, c-Met, IGF-1R, and HSP70 Overexpression after the Resection of Hepatocellular Carcinoma
Gut and Liver ; : 79-87, 2014.
Article in English | WPRIM | ID: wpr-36649
ABSTRACT
BACKGROUND/

AIMS:

The current study examines the expression of molecular biomarkers in hepatocellular carcinoma (HCC) and whether these findings correlate with the clinicopathologic features of the disease and patient survival.

METHODS:

We analyzed the immunohistochemical expression of p53, mammalian target of rapamycin (mTOR), c-Met, and insulin-like growth factor 1 receptor (IGF-1R) heat shock protein 70 (HSP70) with the clinicopathologic features of 83 HCCs.

RESULTS:

p53 expression was higher in the male patients with undifferentiated histological tumor grades, cirrhosis, and portal vein invasion. High 48 c-Met expression correlated with cirrhosis, and high mTOR expression correlated with the tumor grade and cirrhosis. High IGF-1R expression correlated with the tumor grade and cirrhosis. A multivariate analysis identified a significant relationship between the high expression of p53, tumor grade, and portal vein invasion. In addition, a high expression of mTOR was related to tumor grade and cirrhosis, and a high expression of HSP70 was related to portal vein invasion in a multivariate analysis. The Kaplan-Meier survival curve for patients with high versus low Edmondson grades and p53 expression was statistically significant.

CONCLUSIONS:

p53, mTOR, and IGF-1R expression correlated with the Edmondson tumor grade in a univariate analysis, while p53 and mTOR correlated with the Edmondson tumor grade in a multivariate analysis. In addition, the tumor grade was found to predict survival. p53 was primarily related to the clinicopathologic features compared to other markers, and it is a poor prognostic factor of survival.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Biomarkers, Tumor / Retrospective Studies / Risk Factors / Tumor Suppressor Protein p53 / Treatment Outcome / Receptor, IGF Type 1 / Carcinoma, Hepatocellular / HSP70 Heat-Shock Proteins / Disease-Free Survival Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Gut and Liver Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Biomarkers, Tumor / Retrospective Studies / Risk Factors / Tumor Suppressor Protein p53 / Treatment Outcome / Receptor, IGF Type 1 / Carcinoma, Hepatocellular / HSP70 Heat-Shock Proteins / Disease-Free Survival Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Gut and Liver Year: 2014 Type: Article