Hepatoprotective and Anti-cirrhotic Effects of Hypericum patulum Thumb. ex Murr

ABSTRACT

Water extract of Hypericum patulum Thumb. ex Murr. has been proved to possess the effects of decreasing GPT hepatoyeast and bilirubin, inhibiting anti-cirrhotic, decreasing the amount of colagen by 26.4%, antioxidant, amount of MDA of the treated mice decreased by 22.62%. Water extract of Hypericum patulum Thumb. ex Murr. has chronic anti - inflammatory effect on the model causing experimental granuloma, reducing the mass of tumor by 30.22%. In addition, water extract of Hypericum patulum Thumb. ex Murr. has clearly choleretic activities, increasing the number of producing bile by 78.55% as compared with physiological control group. Water extract of Hypericum patulum Thumb. ex Murr. has promising for a medicament for chronic hepatitis activity.