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Comparative study of paired serum and cerebrospinal fluid samples from neurocysticercosis patients for the detection of specific antibody to <i>Taenia solium</i> immunodiagnostic antigen
Tropical Medicine and Health ; 2015.
Article in English | WPRIM | ID: wpr-379239
ABSTRACT
Neurocysticercosis(NCC) is an important disease in central nervous system caused by infectionwith <i>Taenia solium </i>metacestodes. Inaddition to clinical findings and the imaging analysis, the results ofimmunological tests are informative to diagnose NCC. To compare the usefulnessof serum and cerebrospinal fluid (CSF) samples for antibody detection test,paired serum and CSF samples from NCC and other neurological disease patientswere examined by an enzyme-linked immunosorbent assay with low-molecular-weightantigens purified from <i>T. solium</i> cystfluid in a blinded fashion. Sensitivities of both serum and CSF samples were25.0% in inactive NCC cases (n = 4) and 90.9% in active NCC cases (n = 33) and specificitiesof serum and CSF were 100% and 95.8%, respectively. By the combination of serumand CSF samples, sensitivity for active NCC cases became 100%. There was nodifference in the test performance between serum and CSF samples. Based onthese results, we suggest the detection of specific antibodies in serum for thediagnosis of active NCC because of an easy collection of it. However, in caseof the antibody test negative, CSF should be used to confirm NCC and to ruleout other medical disorders of central nerve system. For diagnosis of suspectedinactive NCC cases, antibody detection test using either serum or CSF has alimited diagnostic value and cannot be recommended.

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Index: WPRIM (Western Pacific) Type of study: Diagnostic study Language: English Journal: Tropical Medicine and Health Year: 2015 Type: Article

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Index: WPRIM (Western Pacific) Type of study: Diagnostic study Language: English Journal: Tropical Medicine and Health Year: 2015 Type: Article