Changes and significance of levels of sIL-2R and sICAM-1 in serum and tissue of patients with colorcetal cancer / 肿瘤研究与临床

ABSTRACT

Objective To study the changes of serum and tissue soluble interleukin-2 receptor (slL-2R) and soluble intercellular adhesion moleculer-1 (sICAM-1) in eolorectal cancer and their clinical significance. Methods Serum levels of sIL-2R and sICAM-1 were detected by the double antibody sandwich ELISA method in 44 colorectal cancer patients before and after operation, 28 polyp intestinal and 30 controls. Simultaneously, tissue levels of them were measured in co]oreetal cancer and polyp intestinal. Results The serum sIL-2R[(209.27±127.42) pmol/L] and sICAM-1[(693.22±276.25) ng/ml] in coiorectal cancer were significantly higher than those in the polyp intestinal and controls.The tissue sIL-2R [(233.66±170.22)pmol/L] and sICAM-l[(706.92±286.09) ng/ml] in colorectal cancer were significantly higher than those in the polyp intestinal. The serum and tissue levels of sIL-2R and sICAM-1 in colorectal cancer had relationships with Duke stages and no relationships with the histological differentiation. The levels of serum sIL-2R and sICAM-1 declined remarkably after one month of radical operation, but it decreased illegibly after palliative operation. Conclusion Alterations of serum and tissue sIL-2R and sICAM-1 levels may be used as indicators of diagnosis, choice of operative method, judgement of prognosis in eoloreetal cancer.