Methylation state of p16 gene promoter in peripheral CIM~+ T cells of patients with systemic lupus erythematosus / 中华皮肤科杂志
Chinese Journal of Dermatology
; (12): 22-24, 2010.
Article
in Zh
| WPRIM
| ID: wpr-391773
Responsible library:
WPRO
ABSTRACT
Objective To detect the methylation status of p16 gene promoter in CD4~+ T cells of patients with systemic lupus erythematosus(SEE),and its significance in the pathogenesis of SLE.Methods The pl 6 gene promoter methylation in peripheral CD4~+ T cells was detected with the Taqman probe-based realtime PCR(Methylight)technology in 28 patients with SLE and 20 healthy human controls.Results The methylation rate of p16 gene promoter in peripheral CD4~+ T cells was higher in patients with SLE than that in the controls(35.7%VS 10%,x~2=4.11,P<0.05).There was no correlation between SLE disease activity index (SLEDAI)and the normalized index of methylation(NIM)of p16 gene promoter(r_s=-0.29,P>0.05).Conclusion The methylation status of p16 gene promoter is aberrant in CD4~+ T,ells of SLE patients,suggesting that the hypermethylation of p16 gene plays a certain role in the pathogenesis of SLE.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Dermatology
Year:
2010
Type:
Article