Inhibitory effect of scopolamine on withdrawal syndromes in morphine dependent rats / 第二军医大学学报
Academic Journal of Second Military Medical University
; (12): 351-353, 2001.
Article
in Zh
| WPRIM
| ID: wpr-410485
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WPRO
ABSTRACT
Objective: To observe the inhibitory effect of scopolamine(Spm) and chlopromazine (Clo) on withdrawal syndromes in morphine dependent rats. Methods: The intensity of withdrawal syndromes on the model of morphine dependent rats was recorded after single or muiltiple subcutaneous administration(sc) of Spm and Clo at different doses. Results: Withdrawal syndromes were markedly decreased when single Spm 1 mg/kg and Clo 0.5 mg/kg combined with morphine were injected (P<0.05). Spm+Clo(sc) had much stronger effects on inhibiting withdrawal syndromes after intraperitoneal (ip) naloxone in morphine dependent rats (P<0.01). Conclusion: Spm can act on Ach-receptor and relieve morphine withdrawal syndromes. Clo may have a synergistic action with Spm via α2-receptor in the locus coeruleus of the rat brain stem.
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Language:
Zh
Journal:
Academic Journal of Second Military Medical University
Year:
2001
Type:
Article