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Clinical outcome of early stage breast cancer treated with short-course radiotherapy with concomitant tumor bed boost after breast conserving surgery / 中华放射肿瘤学杂志
Chinese Journal of Radiation Oncology ; (6): 526-529, 2012.
Article in Chinese | WPRIM | ID: wpr-430121
ABSTRACT
Objective To investigate the efficacy,toxicity and cosmetic outcome of short-course radiotherapy with concomitant tumor bed boost after breast-conserving surgery for early stage breast cancer.Methods A total of 306 patients with T1-2 N0-1 M0 breast cancer after breast-conserving surgery were included.160 patients received whole-breast radiation to 45 Gy in 25 fractions followed by tumor bed boost of 14 Gy in 7 fractions (C group).146 patients received whole-breast radiation to 46 Gy in 23 fractions with concomitant tumor bed boost to 60 Gy in 23 fractions (S group).Kaplan-Meier method was used to calculate the local recurrence and overall survival rates and the differences were compared by Logrank test.Chi-square test was used to compared the differences of the clinical characteristics,toxicity and cosmetic outcome between the two groups.Results The follow-up rate was 100%.After a median follow up of 26 months,the 1-,2-and 3-year overall survival rates were 100%.No patient developed local recurrence.In C and S group,the incidence of grade 1 acute skin toxicity was 46.9% and 45.1% (x2 =0.73,P =0.695),grade 2was 16.3% and 13.7% (x2 =0.73,P =0.695).Grade 1 late skin and subcutaneous tissue toxicity developed in 16.9% and 17.1% of patients in C and S group (x2 =0.00,P =0.954).Grade 1 neutropenia occurred in 11.9% and 13.7% of patients in C and S group (x2 =0.23,P =0.633).In C and S group,66.2% and 65.5% of patients had excellent and good cosmetic outcome (x2 =0.01,P =0.927).Conclusions Short-course radiotherapy with concomitant tumor bed boost provides similar results to conventional radiotherapy in local control,toxicity and cosmetic outcome.Long-term follow up is warranted to confirm this finding.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Radiation Oncology Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Radiation Oncology Year: 2012 Type: Article