Relationship of serum 25-hydroxyvitamin D and parathyroid hormone levels with blood pressure in 1 403 community adults / 中华内分泌代谢杂志

ABSTRACT

Objective To investigate the association of serum 25-hydroxyvitamin D (25OHD),parathyroid hormone (PTH),blood glucose,blood lipid,uric acid,obesity,insulin etc with blood pressure.Methods A total of 1 403 residents aged (45.3 ± 14.4) years were enrolled from Guiyang residents during a health survey in 2009.The standard questionnaire survey and physical examination were performed in all subjects.The fasting plasma glucose,postprandial 2 h plasma glucose (2hPG),triglyceride,high density lipoprotein-cholesterol,serum calcium,phosphorus,creatinine,and uric acid were determined by automatic biochemical analyzer,serum insulin by chemiluminescence method,and serum 25OHD and PTH by radioimmunoassay.Results Path analysis showed that age,gender,body mass index (BMI),insulin,25OHD,PTH,2hPG,and triglyceride affected systolic blood pressure,with the repective path coefficients of 0.453,0.294,0.120,-0.106,-0.049,0.047,0.030,and 0.030.BMI,age,gender,insulin,2hPG,triglyceride affected diastolic blood pressure,with the path coefficients 0.348,0.217,-0.146,0.134,0.035,and 0.035 respectively.Insulin,triglyceride,2hPG indirectly influenced blood pressure through BMI.BMI,PTH,and 25OHD had a significant and direct effect on blood pressure.Gender and age directly and indirectly influenced blood pressure through BMI.Conclusion The most significant influential factors on blood pressure are age,serum insulin,triglyceride,and 2hPG in the population of Guiyang.Serum 25OHD is negatively associated with systolic blood pressure while PTH level is positively associated with systolic blood pressure.