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Optimization and Preliminary Evaluation the Formulation of Self-microemulsifying Drug Delivery System of Potassium Dehydroandrographolidi Succinas / 世界科学技术-中医药现代化
Article in Chinese | WPRIM | ID: wpr-463971
Responsible library: WPRO
ABSTRACT
The self-microemulsion formulation of potassium dehydroandrographolidi succinas (PDS) has been optimized and the performance in vitro has been evaluated preliminary. Kinds of prescription accessories were screened by solubility based on the emulsifying result and efficiency, particle size of emulsions. The optimal formulation composition and compatibility proportion were determined by orthogonal design and pseudo-ternary phase diagrams. The appearance, particle size, Zeta potential and stability of this formulation were also investigated. The optimized prescription of PDS was 10% MCT, 40% Tween-20 and 50% glycerol. It can spontaneously form a transparent pale blue opalescent emulsion with emulsification time 31.27 s, particle size 37.1 nm, Zata potential -17.4 mV and good stability.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: World Science and Technology-Modernization of Traditional Chinese Medicine Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: World Science and Technology-Modernization of Traditional Chinese Medicine Year: 2015 Type: Article