A Case of Simultaneously Occurred Amiodarone-induced Hepatitis and Hypothyroidism / 대한소화기학회지
The Korean Journal of Gastroenterology
; : 59-63, 2013.
Article
in Ko
| WPRIM
| ID: wpr-46501
Responsible library:
WPRO
ABSTRACT
Amiodarone is a di-iodated benzofuran derivative that is commonly used to treat patients with various cardiac arrhythmias. It is associated with side effects that involve the liver, thyroid, and other organs. Approximately 1-3% of patients treated with amiodarone suffer from symptomatic liver disease. Thyroid dysfunction occurs in 10% of patients treated with amiodarone. A 65-year-old woman with coronary heart disease and atrial fibrillation was administered with amiodarone. She developed nausea, vomiting, dyspepsia, and sweating within 9 months of amiodarone administration (200 mg orally once a day). Results of the laboratory finding showed increased hepatic enzymes, and low thyroid hormone levels. A liver biopsy showed irregular arrangement of hepatocytes and diffuse micro- and macrovesicular fatty changes. Electron microscopy findings showed pleomorphic mitochondria with crystalloid inclusions and membrane-bound lysosomal structures. The liver and thyroid functions returned to normal, after the amiodarone was stopped. We describe an unusual case in which amiodarone induced hepatitis and hypothyroidism simultaneously. Physicians should take a close look to the adverse event when using amiodarone which can cause adverse effects in multiple organs.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Arrhythmias, Cardiac
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Fibrosis
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Microscopy, Electron
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Tomography, X-Ray Computed
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Treatment Outcome
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Chemical and Drug Induced Liver Injury
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Amiodarone
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Hypothyroidism
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Mitochondria
Limits:
Aged
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Female
/
Humans
Language:
Ko
Journal:
The Korean Journal of Gastroenterology
Year:
2013
Type:
Article