Association of chronic kidney disease and cerebral microbleeds in patients with ischemic stroke / 中华神经科杂志
Chinese Journal of Neurology
;
(12): 747-751, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-469012
ABSTRACT
Objective To investigate the association between the presence of cerebral microbleeds and chronic kidney disease in patients with ischemic stroke.Methods Patients with ischemic stroke within 1-6 months were consecutively recruited.Cranial MRI was taken within two weeks after recruitment.Cerebral microbleeds were assessed using Microbleed Anatomical Rating Scale on gradient echo MRI.Demographics including sex,age and risk factors were obtained.Chronic kidney disease was defined and classified according to National Kidney Fundation-Kidney Disease Outcome Quality Initiative Guideline.Glomerular filtration rate (GFR) was estimated by using the abbreviated Modification of Diet in Renal Disease equation.Results Of the 636 patients included,mean age was (59.8 ± 10.1) years,435 (68.4%) were male.Sixty-six had decreased estimated GFR (eGFR; < 60 ml · min-1 · 1.73 m-2).Two hundred and one (31.6%) patients had cerebral microbleeds,which were most commonly located in deep or infratentorial location (133/201,66.2%).The presence of cerebral microbleeds was much higher in patients with decreased eGFR than the others (48.5% (32/66) vs 29.6% (169/570),x2 =9.709,P =0.002).Age,history of hypertension and decreased eGFR were associated with the presence of cerebral microbleeds in univariate analysis.In multivariate analysis,decreased eGFR was independently associated with the presence of cerebral microbleeds in deep or infratentorial location (OR =1.457,95% CI 1.044-2.034,P =0.027),but not associated with the presence of cerebral microbleeds in pure lobe.Conclusion Impaired kidney function is associated with the presence of cerebral microbleeds in deep or infratentorial regions in patients with ischemic stroke.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Risk factors
Language:
Chinese
Journal:
Chinese Journal of Neurology
Year:
2014
Type:
Article
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