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Relationship between Tumor Necrosis Factor-α Gene Polymorphism and Mild Cognitive Impairment in Patients with Type 2 Diabetes Mellitus / 天津医药
Tianjin Medical Journal ; (12): 94-96, 2010.
Article in Chinese | WPRIM | ID: wpr-472929
ABSTRACT

Objective:

To investigate the relationship between tumor necrosis factor-α (TNF-α)-308A/G gene polymorphism and mild cognitive impairment(MCI)in patients with type 2 diabetes mellitus(T2DM),and their correlative risk factors thereof.

Methods:

Forty cases of T2DM with MCI and 80 cases of T2DM without MCI were selected for this study.The polymorphism of the TNF-α-308A/G was detected by PCR-restriction fragment length polymorphism (PCR-RFLP).According to the clinical data,such as course of disease,plasma glucose,plasma fat and body mass index(BMI),the independent risk factors of T2DM and MCI were analyzed by non-conditional logistic regression.

Results:

The frequency of TNF-α2 allele was significantly higher in the group of T2DM with MCI than that without MCI (P<0.01).The indexes of the statistical significant difference between the two groups were the age,course of disease,postprandial blood glucose(P2BG),glycosylated hemoglobin,body mass index,family history of T2DM,hypertension,diabetic retinopathy,diabetic peripheral neuropathy and TNF-α.The independent risk factors included TNF-α,diabetic peripheral neuropathy,diabetic retinopathy,age and P2BG.

Conclusion:

There is a significant relationship between TNF-α2 allele and T2DM with MCI.There is a significant relationship between the age,control of plasma glucose and microvaseular complication of T2DM with the cognitive funotion.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Risk factors Language: Chinese Journal: Tianjin Medical Journal Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Risk factors Language: Chinese Journal: Tianjin Medical Journal Year: 2010 Type: Article