Angiogenic factors in osteonecrosis of the femoral head / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 2197-2205, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-486181
ABSTRACT
BACKGROUND:
A variety of angiogenic factors are involved in bone healing after osteonecrosis of the femoral head.OBJECTIVE:
To explore the role and mechanism of angiogenic factors in osteonecrosis of the femoral head.METHODS:
A computed-based online search of PubMed, Google and SpringerLink databases was performed using the key words of “angiogenic factors, osteonecrosis of the femoral head, vascular endothelial growth factor, angiopoietin-1, fibroblast growth factor-2, hypoxia inducible factor-1, calcitonin gene related peptide and hypoxia inducible factor-1α” for literatures published from December 1980 to May 2015. RESULTS ANDCONCLUSION:
Finaly, 68 articles were included. Bone angiogenesis which is dependent on special signaling factors in the microenvironment is closely linked with bone repair. A variety of cytokines, such as vascular endothelial growth factor, angiopoietin-1, fibroblast growth factor-2, platelet-derived growth factor, calcitonin gene-related peptide, and hypoxia inducible factor-1α, have been identifiedto control angiogenesis in different ways and be involved in the repair of necrotic femoral head.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Tissue Engineering Research
Year:
2016
Type:
Article
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