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Research progress of adult animal models of growth hormone deficiency and bone metabolism / 中国实验动物学报
Article in Chinese | WPRIM | ID: wpr-486207
Responsible library: WPRO
ABSTRACT
Objective To explore the establishment methods of animal models of adult growth hormone deficiency, and to provide a good model for experimental research and treatment for abnormal bone metabolism caused by growth hor-mone deficiency.Methods The methods of establishment of animal models of adult growth hormone deficiency were re-viewed and evaluated refering to literature.Results There were three methods including spontaneous lack-of, pituitecto-mized and gene knockout can establish animal models of adult growth hormone deficiency.Conclusions Hypophysecto-mized animal models are inexpensive and easy to create, but not suitable for studying the relationship between growth hor-mone and bone metabolism.Spontaneous lack-of and gene knockout models are specific growth hormone deficiency and of great research significance in exploring the relationship between growth hormone and bone metabolism.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Acta Laboratorium Animalis Scientia Sinica Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Acta Laboratorium Animalis Scientia Sinica Year: 2016 Type: Article