Identification of Proteins Induced at Hypoxic and Low pH Conditions in Mycobacterium tuberculosis H37Rv
Journal of Bacteriology and Virology
; : 59-68, 2006.
Article
in Ko
| WPRIM
| ID: wpr-49010
Responsible library:
WPRO
ABSTRACT
Mycobacterium tuberculosis likely reside within a granuloma as a dormant state. An area of necrosis forms at the center of lung granulomas. Within this area, the bacteria are deprived of nutrients and exposed to harsh conditions, including low pH and anoxia. The response of M. tuberculosis to low pH and low oxygen conditions was investigated in both cellular and extracellular proteins by two-dimensional polyacrylamide gel electrophoresis analysis and MALDITOF. Several proteins intensively expressed under low pH and/or hypoxic conditions were found. In the culture filtrate, PhoS1 (Rv0934) and ScoB (Rv2503c) were found in significant amounts under both the low oxygen and acidic stress conditions. These results indeed extend our understanding of acidic response as well as hypoxic in M. tuberculosis and provide an important insight into physiology of the latent bacilli.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Oxygen
/
Physiology
/
Bacteria
/
Tuberculosis
/
Electrophoresis, Polyacrylamide Gel
/
Granuloma
/
Hydrogen-Ion Concentration
/
Lung
/
Hypoxia
/
Mycobacterium
Type of study:
Diagnostic_studies
Language:
Ko
Journal:
Journal of Bacteriology and Virology
Year:
2006
Type:
Article